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企業情報 Research & Development, Production [Institute introduction]

Contributing to innovation in medical care through original technologies and ideas

The Nipro Group has three research and development centers each respectively focusing on medical equipment, pharmaceutical drugs, and production technology at the Life Science Site in Kusatsu City, Shiga Prefecture.
At the Nipro Institute for Medical Practice ("Nipro iMEP"), located on the same premises as the Research and Development laboratory, we receive health care professionals for training in the use of our medical equipments. We have thus constructed a system by which we can obtain feedback directly from professionals about our products so that we may promptly reflect it in our research and development for new and improved products.
At these facilities, the Nipro Group creates original products that respond to user needs.

Research and Development Laboratory and Pharmaceutical Research Center


Research and Development
Laboratory/Production Technology
Center

Pharmaceutical Research Center

Products of cellular and regenerative medicine

We are developing automatic culturing devices for ES/iPS cells and mesenchymal stem cells, whose application to regenerative medicine and drug development is expected.
We are conducting Research and Development to realize the practical use of patients' own bone marrow stem cells in the manufacture of cell function-affecting drugs (products of regenerative medicine) for the treatment of cerebral infarction and spinal cord injury, which tend to leave patients with such aftereffects as movement and functional disorders. An early realization of this practical application is awaited to offer a new treatment for many patients troubled by aftereffects.

Dialysis-related and general medical devices

We promote the development of medical devices related to dialysis, catheters, infusions, and infertility treatment, as well as safety-assured disposable medical devices. Our dialysis-related products include dialysis machines, dialyzers, blood tubing sets, and related pharmaceuticals. Our catheter-related products include elastomertric disposable infusion pump and implanted ports. We develop infusion-related devices, such as antithrombogenic catheters, infusion sets for children, and the needle connection system of the preventable-contamination. The devices for infertility treatment include ovum pick up needles, sperm screening dishes, and embryo transfer catheters. The safety-assured products include needles designed to prevent needlestick injuries. Our focal points are high functionality, highly added value, ease of use, and safety.

Circulatory organ- and intervention-related products

We are working on the development and introduction of circulatory organ-related medical devices for the treatment and diagnosis of heart diseases, such as PTCA balloon catheters, which are inserted into narrowed coronary arteries and are expanded for treatment; and thrombosis-trapping catheters that capture thrombosis and foreign objects during treatment.

Artificial organs

We are working on the development and commercialization of artificial organs, including artificial lungs that collect carbon dioxide from blood and send oxygen in place of real lungs during a heart operation; artificial lungs with a venous blood reserving system that filters and collects blood after hemorrhage; and arterial filters that remove thrombosis and air bubbles generated in the circulatory circuit.

Test and diagnosis-related products

We are working on the development of new diagnostic drugs that quickly produce diagnostic results or enable to determine therapeutic effects, as well as medical test systems that are easy to use at any location.
We have developed and commercialized reagents for the diagnosis or treatment of Alzheimer's disease, rapidly progressive glomerulonephritis, and rheumatism, as well as genetic test devices for multidrug-resistant tuberculosis, osteoporosis treatment devices, and steroid-responsive genetic test kits. These products are intended for tailor-made medical care (*). We have also developed blood glucose measuring devices that diabetics can use to take measurements by themselves.

* Tailor-made medical care: Medical care involving treatment methods that are individually designed for specific patients in consideration of their pathological conditions, especially based on genetic diagnosis.

Injection products

We are actively developing injection kits that are easy to handle in clinical situations. We are also developing pre-mixed injection bags which already contain pre-diluted pharmaceutical preparations and powder-liquid double-bag kits (containing powdered drug and dissolving solution).

Oral solids

We develop drug delivery systems for general orally administered pharmaceutical drugs, as well as high value-added drugs that are specially designed for greater ease of administration, such as oral tablets that have a quick disintegrating property in the oral cavity without water.

Medical supplies for external application

We develop medical adhesive tape and cataplasms that feature excellence in terms of thickness, lightness, adhesiveness, elasticity, and so forth, with an eye to market launches outside Japan. The Pharmaceutical Research Center engages in the development of all forms of pharmaceutical drugs, including injections, oral drugs, and externally applied products.

Cancer drugs and biosimilars

In the anti-cancer and biologics market, which is growing rapidly at the moment and in which their medicines are generally expensive, lower-priced generics are preferred. We are actively working on the development of low-priced, high-quality generics that ensure clinical safety, thereby helping reduce ever-increasing pharmaceutical costs.

High-performance medical containers

We develop high-performance containers that are easy and safe to use and effective in safely preserving medical drugs and supplies. We have commercialized double-bag kits, double-chamber pre-filled syringes, half kits, and preservation-free eyedroppers. Components and manufacturing equipment for these containers can also be manufactured within the Nipro Group. Our container design is premised on a totally integrated manufacturing process covering all the way to finished products.

Medical glass products

We have developed new technologies applied to glass containers and devices for medical use, such as pre-filled syringes, vials, and ampoules, which are highly resistant to heat, impact, and chemicals. We also develop and produce processing machines used for the manufacturing of ampoules and other products, and continue to develop new processing technologies.

CR Center

At Nipro, we take a unique approach: our CR Center handles all the duties and operations related to clinical studies, application for governmental approval, negotiations for reimbursement prices, and post-marketing surveillance in a total, integrated manner.
A newly developed medical device that is highly novel and has the potential of significantly affecting human health must undergo legally prescribed steps before it becomes usable in actual medical scenes. These steps include clinical studies required for application for governmental approval, application for governmental approval, approval by the MHLW (Minister for Health, Labor and Welfare,) and the determination of the reimbursement price. Once a new medical device is marketed, a large-scale survey is sometimes conducted on the state of use of the device (post-marketing surveillance). Very often, duties related to these steps are handled by different divisions within a medical device manufacturing company.

Production Technology Center

Supporting Nipro's production in two areas, equipment and systems

The Production Technology Center is in charge of development relating to production technologies for the entire Nipro Group. It designs equipment and facilities for the Nipro Group's factories to respond to all types of needs. In addition to equipment and facilities, the Center also develops specific technologies for designing systems, such as electric systems, circuits, and programs, thereby contributing to the enhancement of the Nipro Group's overall productivity.

  • Design and manufacturing of equipment and facilities
  • Inspection, analysis, and maintenance of equipment and facilities
  • Development of production technologies
  • Design and manufacturing of electric systems, circuits, and programs
  • Inspection, analysis, and maintenance of electric systems, circuits, and programs

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